I. Shimaoka et al., EFFECTS OF A COPPER-BINDING PEPTIDE FROM THE MUSHROOM GRIFOLA-FRONDOSA ON INTESTINAL COPPER ABSORPTION, Nutrition research, 14(9), 1994, pp. 1331-1337
The effect of a copper-binding peptide, purified previously from the f
ruit bodies of the mushroom, Grifola frondosa, on copper absorption wa
s investigated by using portal cannulated rats under unanesthetized an
d unrestrained conditions. When the copper-binding peptide was infused
into the duodenum together with copper, the amount of copper in porta
l blood was significantly increased compared with the absence of this
peptide. Furthermore, the remarkable accumulation of copper in the liv
er was also observed. These results suggest that the copper-binding pe
ptide enhances copper intestinal absorption and accumulation in the li
ver.