INTERLEUKIN-8 ANTITUMOR EFFECT IS ASSOCIATED WITH A LOCAL INFILTRATION BUT NOT WITH A SYSTEMIC ACTIVATION OF T-LYMPHOCYTES

Authors
REISSER D LEJEUNE P LAGADEC P ONIER N DASILVA C LINDLEY I JEANNIN JF
Citation
D. Reisser et al., INTERLEUKIN-8 ANTITUMOR EFFECT IS ASSOCIATED WITH A LOCAL INFILTRATION BUT NOT WITH A SYSTEMIC ACTIVATION OF T-LYMPHOCYTES, Anticancer research, 14(3A), 1994, pp. 977-979
Citations number
10
Categorie Soggetti
Oncology
Journal title
Anticancer research → ACNP
ISSN journal
02507005
Volume
14
Issue
3A
Year of publication
1994
Pages
977 - 979
Database
ISI
SICI code
0250-7005(1994)14:3A<977:IAEIAW>2.0.ZU;2-P
Abstract
In a model of colon cancer in rats (peritoneal carcinomatosis), IL-8 w as found to have a highly reproducible anti-tumoural effect. During IL -8-induced tumour regression the infiltration of nodules by CD4(+) T l ymphocytes was enhanced. However splenic lymphocytes did not prolifera te in response to tumour cells in vitro. IL-8 antitumour effect was as sociated with a local but not with a systemic activation of T lymphocy tes.