REDUCED FORMATION OF HIGH-MOLECULAR-WEIGHT DNA IN MURINE GLIOMAS TREATED WITH NITROSOUREA AND CHLORPROMAZINE

Authors
AAS AT SALFORD LG LONN S LONN U
Citation
At. Aas et al., REDUCED FORMATION OF HIGH-MOLECULAR-WEIGHT DNA IN MURINE GLIOMAS TREATED WITH NITROSOUREA AND CHLORPROMAZINE, Anticancer research, 14(3A), 1994, pp. 1133-1136
Citations number
11
Categorie Soggetti
Oncology
Journal title
Anticancer research → ACNP
ISSN journal
02507005
Volume
14
Issue
3A
Year of publication
1994
Pages
1133 - 1136
Database
ISI
SICI code
0250-7005(1994)14:3A<1133:RFOHDI>2.0.ZU;2-3
Abstract
We have examined the formation of DNA in rat glioma cells. Cytotoxicit y was induced in the cells using BCNU (1,3-bis(2-chlolaethyl)-1-nitros o-urea) in the presence or absence of CPZ (chlorpromazine). There was impaired formation of DNA in cells treated with BCNU. This was further enhanced in cells treated with both BCNU and CPZ. In the latter case we did not find any intact high molecular weight DNA.