3RD DERIVATIVE SPECTROPHOTOMETRIC DETERMINATION OF METOMIDATE FROM AQUEOUS-SOLUTION

The third derivative spectrophotometric method has been proposed for t he determination of metomidate from aqueous solution. By hydrolysis of metomidate, D,L-1-(1-phenylethyl)-imidazole-5-carboxylic acid is form ed. Determining the absolute value of the third derivative spectra in the ''zero-crossing'' point, the concentration of metomidate can be ca lculated directly without any interferences. The validity of the metho d was confirmed using synthetic mixtures. Kinetic investigation of the degradation rate of metomidate revealed that the proposed method is s tability indicating.