3RD DERIVATIVE SPECTROPHOTOMETRIC DETERMINATION OF METOMIDATE FROM AQUEOUS-SOLUTION

Citation
M. Surmeian et al., 3RD DERIVATIVE SPECTROPHOTOMETRIC DETERMINATION OF METOMIDATE FROM AQUEOUS-SOLUTION, Analytical letters, 27(12), 1994, pp. 2281-2290
Citations number
9
Categorie Soggetti
Chemistry Analytical
Journal title
ISSN journal
00032719
Volume
27
Issue
12
Year of publication
1994
Pages
2281 - 2290
Database
ISI
SICI code
0003-2719(1994)27:12<2281:3DSDOM>2.0.ZU;2-O
Abstract
The third derivative spectrophotometric method has been proposed for t he determination of metomidate from aqueous solution. By hydrolysis of metomidate, D,L-1-(1-phenylethyl)-imidazole-5-carboxylic acid is form ed. Determining the absolute value of the third derivative spectra in the ''zero-crossing'' point, the concentration of metomidate can be ca lculated directly without any interferences. The validity of the metho d was confirmed using synthetic mixtures. Kinetic investigation of the degradation rate of metomidate revealed that the proposed method is s tability indicating.