TRANSCRIPTIONAL REGULATION OF THE PCNA PROMOTER BY P53

We have examined the ability of p53 to affect transcription from the P CNA promoter in a number of cell types. In HeLa cells, p53 activates t he PCNA promoter whereas in CV1, CHO, L929, and Saos-2 cells the same promoter is strongly repressed. By using stepwise deletions of the PCN A promoter, we have identified two potential regions of the promoter w hich are important for the ability of p53 to activate transcription in HeLa cells, (C) 1994 Academic Press, Inc.