SOMATOSTATIN-14 INCREASES THE INOSITOL-1,4,5-TRISPHOSPHATE CONTENT INVARIOUS AREAS OF THE BRAIN

The effects of somatostatin-14 on inositol-1,4,5-trisphosphate (IP3) c ontent were examinated in rat pituitary, hippocampus and cortex homoge nates. Somatostatin increased IP3 concentration in all these investiga ted regions in a dose- and time-dependent manner. Maximal increase of IP3 content was found in the pituitary homogenate, and in the hippocam pal and cortex homogenates the IP3 argumentation was slightly smaller. Time-response studies showed that this effect declined with extended time of incubation. These results suggest that IP3 is involved in the mechanism of action of somatostatin in brain. (C) 1994 Academic Press, Inc.