HSP70RY - FURTHER CHARACTERIZATION OF A NOVEL MEMBER OF THE HSP70 PROTEIN FAMILY

Hsp70RY was identified as a member of the hsp70 protein family on the basis of cDNA sequence homology (Fathallah, et. al. (1993) J. Immunol. 151, 810-813). We have shown that mRNA encoding hsp70RY is expressed in a variety of human cell lines and that mRNA expression remains unch anged in human promyelocytic HL-60 cells induced to differentiate with phorbol 12-myristate 13-acetate (PMA). We have also shown that the pr edicted amino acid sequence of hsp70RY diverges significantly from the other human hsp70 proteins and that it contains a unique glutamate-ri ch region near its carboxy-terminus. Finally, we have demonstrated the existence of a murine homolog of hsp70RY. (C) 1994 Academic Press, In c.