I. Varga et al., POTENTIATION OF IONOPHOROUS ANTICOCCIDIALS WITH DIHYDROQUINOLINES - BATTERY TRIALS AGAINST EIMERIA-TENELLA IN CHICKENS, International journal for parasitology, 24(5), 1994, pp. 689-694
Seven battery tests, employing a total of 1344 Hybro cockerels, were c
onducted in order to study the interaction between ionophorous anticoc
cidials and a new dihydroquinoline-type antioxidant known as duokvin.
A significant, non-selective, toxic interaction was established, resul
ting in growth depression and improved anticoccidial efficacy against
Eimeria tenella and E. mitis in these chickens. The duokvin itself sho
wed no appreciable activity against the coccidia. The adverse effects
of the interaction were eliminated, and the anticoccidial efficacy of
the approved levels of ionophores was maintained, when the dietary lev
els of monovalent cation ionophorous monensin, salinomycin and narasin
were reduced to approximately 12% in the presence of 120 p.p.m. duokv
in. No adverse effects on the growth of chickens appeared in the combi
nation with maduramicin, yet the enhancement of anticoccidial activity
allowed an approx. 50% reduction of this ionophore as well.