POTENTIATION OF IONOPHOROUS ANTICOCCIDIALS WITH DIHYDROQUINOLINES - BATTERY TRIALS AGAINST EIMERIA-TENELLA IN CHICKENS

Seven battery tests, employing a total of 1344 Hybro cockerels, were c onducted in order to study the interaction between ionophorous anticoc cidials and a new dihydroquinoline-type antioxidant known as duokvin. A significant, non-selective, toxic interaction was established, resul ting in growth depression and improved anticoccidial efficacy against Eimeria tenella and E. mitis in these chickens. The duokvin itself sho wed no appreciable activity against the coccidia. The adverse effects of the interaction were eliminated, and the anticoccidial efficacy of the approved levels of ionophores was maintained, when the dietary lev els of monovalent cation ionophorous monensin, salinomycin and narasin were reduced to approximately 12% in the presence of 120 p.p.m. duokv in. No adverse effects on the growth of chickens appeared in the combi nation with maduramicin, yet the enhancement of anticoccidial activity allowed an approx. 50% reduction of this ionophore as well.