Vomitting, abdominal distension, and feeding intolerance are common fi
ndings following brain injury in children, and are usually attributed
to the brain injury or to delayed gastric emptying: a specific cause i
s usually not sought. We report six children who developed mild to mod
erate pancreatitis at least 7 days following apparently isolated brain
injury, a previously unreported association. Five of the six patients
received drugs that are known or suspected pancreatotoxins; all recov
ered without changes in the medications. When children develop feeding
intolerance or upper gastrointestinal symptoms following traumatic br
ain injury, pancreatitis should be suspected.