C. Hochreiter et al., RIGHT-VENTRICULAR AND LEFT-VENTRICULAR PERFORMANCE 10 YEARS AFTER MUSTARD REPAIR OF TRANSPOSITION OF THE GREAT-ARTERIES, The American journal of cardiology, 74(5), 1994, pp. 478-482
Twenty-two late survivors of Mustard repair of transposition of the gr
eat arteries underwent treadmill exercise testing to assess exercise e
ndurance, and radionuclide cineangiography to measure rest and exercis
e right ventricular (RV) and left ventricular (LV) ejection fraction (
EF). Mean age at Mustard repair was 1.8 +/- 2.4 years and at initial e
xercise study 14.1 +/- 4.5 years. All patients were asymptomatic at st
udy entry. Treadmill endurance time (9 to 12 minutes) was within the n
ormal range for age in 18 of 20 patients. LVEF and RVEF at rest were w
ithin normal limits (55 +/- 8% and 52 +/- 9%, respectively). All LVEFs
and RVEFs during exercise were also within the normal range (64 +/- 8
% and 57 +/- 9%, respectively). However, the magnitude of increase in
EF (rest to exercise) was subnormal for the right ventricle in 1 patie
nts and for the left ventricle in 2 patients. Exercise RVEF was higher
in patients with simple transposition who underwent repair at <1 year
of age than in those who underwent operation at age >1 year (62 +/- 1
0% vs 52 +/- 7%). Serial study in 6 patients revealed no change in ave
rage RVEF or LVEF after an average interval of 4.4 years. One patient
with complex transposition subsequently developed refractory congestiv
e heart failure requiring cardiac transplantation. It is concluded tha
t exercise endurance and LVEF and RVEF at rest and exercise are genera
lly well preserved up to 19 years after Mustard repair, particularly i
n cases of simple transposition of the great arteries repaired before
1 year of age.