AN EXPEDITIOUS ROUTE TO DIHYDROXY-5-BETA-ANDROSTANE-17-BETA-CARBOXALDEHYDE

Authors
GOBBINI M TORRI M
Citation
M. Gobbini et M. Torri, AN EXPEDITIOUS ROUTE TO DIHYDROXY-5-BETA-ANDROSTANE-17-BETA-CARBOXALDEHYDE, Synthetic communications, 27(6), 1997, pp. 1115-1122
Citations number
26
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Synthetic communications → ACNP
ISSN journal
00397911
Volume
27
Issue
6
Year of publication
1997
Pages
1115 - 1122
Database
ISI
SICI code
0039-7911(1997)27:6<1115:AERTD>2.0.ZU;2-5
Abstract
An efficient and practical synthesis of 3 beta, 14 beta-dihydroxy-5 be ta-androstane-17 beta-carboxaldehyde is described. The key oxidative c leavage of the unsaturated lactone of 3-acetyldigitoxigenin 1 utilises RuO4 as catalytic and NaIO4 as stoichiometric oxidants.