ASSOCIATION OF HUMAN APOLIPOPROTEIN AI CIII/AIV GENE-CLUSTER POLYMORPHISMS WITH LIPID DISORDERS/

Polymerase chain reaction with subsequent restriction analysis (SacI, PstI, PvuII, MspI) were applied to study the AI/CIII/AIV gene cluster polymorphisms in the Moscow population, searching for their possible a ssociation with lipid metabolic indices, such as total cholesterol (Ch ), high-density lipoprotein cholesterol, triglycerides (TG), apolipopr otein AI, apolipoprotein B, and the apoB/AI ratio. Correlations were f ound between elevated indices and increased frequency of uncommon alle les at the following sites: (Ch) SacI, PvuII, MspI; (TG) SacI, MspI; ( apoB) SacI, PvuII; (apoB/AI) PvuII. No correlation was observed betwee n the lipid indices and the frequency of PstI-polymorphic alleles. Com binations of uncommon alleles such as P2S2, P2M2, M2S2, P2T2, and S2T2 were found to be associated with lipid disorders probably conducive t o atherosclerosis.