Se. Lee et al., EXPRESSION OF C-ERBB-2 PROTEIN IN NORMAL AND NEOPLASTIC UROTHELIUM - LACK OF ADVERSE PROGNOSTIC EFFECT IN HUMAN URINARY-BLADDER CANCER, Anticancer research, 14(3B), 1994, pp. 1317-1324
The clinical significance of c-erb B-2 expression in urinary bladder c
ancer remains controversial. We performed an immunohistochemical study
to examine the expression of c-erb B-2 in non-neoplastic urothelium (
n = 12) and transitional cell carcinoma of the urinary bladder (n = 82
). c-erb B-2 protein was localized in superficial and some intermediat
e cells of non-neoplastic urothelium. A total of 29 out of 82 (35%) tu
mors were positive for c-erb B-2 over-expression. There was no signifi
cant association of c-erbB-2 expression with tumor grade (p = 0.12), s
tage (p = 0.93), DNA ploidy status (p = 0.56) and the sex of patients
(p = 0.5). Expression of epidermal growth factor receptor and Ki-67 in
dex was available in 33 cases. Both parameters showed no apparent asso
ciation with c-erbB-2 expression (p = 0.53 and 0.58 respectively). Fac
tors correlated with poor patient survival by univariate analysis were
tumor stage (p = 0.0001), tumor grade (p = 0.001), developent of seco
nd recurrence (p = 0.002) and negative expression of c-erbB-2 (p = 0.0
17). Important indicators associated with first recurrence were tumor
stage (p = 0.028), and c-erbB-2 expression with the risk of second rec
urrence (p = 0.031). Multivariate survival analysis revealed that tumo
r stage was among the most important prognostic factors (p = 0.029), f
ollowed by tumors without c-erbB-2 expression (p = 0.031) with a media
n follow-up at 46 months. The age of patients and c-erbB-2 expression
were significantly associated with developing second recurrence (p = 0
.031 and 0.046 respectively. The results indicate that expression of c
-erbB-2 is independent of the stage and grade of bladder cancer. Altho
ugh c-erbB-2 status can discriminate subpopulations with a high risk o
f recurrence, evaluation of its expression in paraffin-embedded tumors
does not indicate poor prognosis for patients with urinary bladder ca
ncer. To address this discrepancy a better understanding of the regula
tory mechanism and physiological properties of c-erbB-2 protein in uro
thelium is required.