Jc. Tonn et al., IN-VITRO CHEMOSENSITIVITY TEST OF MALIGNANT GLIOMAS - CLINICAL RELEVANCE OF TEST-RESULTS INDEPENDENT OF ADJUVANT CHEMOTHERAPY, Anticancer research, 14(3B), 1994, pp. 1371-1375
Tumor specimens of malignant human gliomas were processed in a colony
forming assay (CFA, n=70) and a metabolic rest system (MTT-test, n=49)
for in-vitro chemosensitivity testing. The clinical data as well as t
he complete follow-up of these patients were obtained until their deat
h or at least 2 years of survival. By means of multivariate statistica
l analysis we demonstrate that both test systems are not influenced by
biometrical data of the patient of histopathological parameters of th
e tumor. According to the COX regression model the results of both ass
ays are per se no prognostic factor when regarded independently of add
itional treatment. However, in 33 patients treated with either ACNU or
BCNU, a prospective correlative trial clearly demonstrates a predicti
ve value of the CFA in adjuvant chemotherapy of gliomas.