EFFECT OF TREATMENT ON ESTABLISHED OSTEOPOROSIS IN YOUNG-WOMEN WITH AMENORRHEA

Citation
B. Gulekli et al., EFFECT OF TREATMENT ON ESTABLISHED OSTEOPOROSIS IN YOUNG-WOMEN WITH AMENORRHEA, Clinical endocrinology, 41(3), 1994, pp. 275-281
Citations number
25
Categorie Soggetti
Endocrynology & Metabolism
Journal title
ISSN journal
03000664
Volume
41
Issue
3
Year of publication
1994
Pages
275 - 281
Database
ISI
SICI code
0300-0664(1994)41:3<275:EOTOEO>2.0.ZU;2-W
Abstract
BACKGROUND AND OBJECTIVE Amenorrhoea in women of reproductive age caus es loss df bone mineral. This study assessed the effect of treatment o f amenorrhoea on bone mineral density. DESIGN Serial measurements of b one mineral density were obtained in women receiving treatment for ame norrhoea. PATIENTS Eighty-five women aged 17-40 with a past or current history of amenorrhoea, from various causes, with median duration of 46.5 months (range 8 months-21 years). MEASUREMENTS Bone mineral densi ty in the lumbar spine was measured by dual-energy X-ray absorptiometr y. RESULTS Initial vertebral bone mineral density was low, mean 0.85 ( SD 0.10) g/cm(2). After an interval of 19.6 (SD 7.5) months on treatme nt there was a highly significant increase to 0.89 (SD 0.10) g/cm(2) ( P < 0.0005). This was equivalent to a gain in bone mass of 2.1% per ye ar (95% confidence interval 1.5-2.8%). Improvement was seen in all dia gnostic groups (except polycystic ovary syndrome) and with all types o f therapy. We observed no difference in the response of previously unt reated patients compared with those already on treatment, nor any chan ge in response with increasing duration bf treatment. No new fractures were reported during the study. CONCLUSIONS Bone mineral density in y oung women with amenorrhoea is improved by appropriate treatment, but recovery is not substantial. Hence early diagnosis and therapy is esse ntial to prevent bond loss.