INFLUENCE OF SYNTHETIC ANTIOXIDANT PHENOZ AN-K ON RETRIEVAL OF DISSOCIATED RESPONSES AND BRAIN PHOSPHOLIPID CONTENT IN WISTAR AND KM RATS

Male Wistar rats were trained to perform dissociated conditioned react ions with food reinforcement in norm and under the action of pentobarb ital (15 mg/kg). Retrieval of the learned tasks was investigated after isolated injections of synthetic antioxidant phenozan-K (40 mg/kg) an d in combination with pentobarbital (7,5 mg/kg). In contrast to the re sults obtained with KM rats, in Wistar rats the influence of the antio xidant on pentobarbital effects was not detected. Comparative study of brair phospholipid content in rats revealed significant distinctions between the strains after pharmacological influences. It was supposed that the effects of phenozan-K depended on the initial brain phospholi pid content. This may be one of the reasons of phenozan-K-induced modi fications of retrieval in KM but not Wistar rats.