PECULIARITIES OF THE REORGANIZATION OF RA TS CIRCADIAN MOTILITY AFTERPHOTOPERIOD SHIFT IN THE EXPERIMENTAL DEPRESSION

Gradual reorganization of the locomotor activity of rats after a shift in the photoperiod was disrupted under the influence of depressogenic agents (reserpine or chronic pain stress). After the chronic use of t he antidepressant amitriptiline the disruption of the reorganization o f the daily motor activity typical for reserpine was not observed conf irming a specificity of these changes. The results suggest that in the experimental model of depression there arise conditions for functiona l disturbance of the circadian pacemaker and an increase of sensitivit y to the photic Zeitgeber.