DYNAMIC ENERGY BUDGETS AFFECT KINETICS OF XENOBIOTICS IN THE MARINE MUSSEL MYTILUS-EDULIS

A dynamic energy budget model is applied to describe uptake and elimin ation kinetics of xenobiotics in the mussel Mytilus edulis. A multi-co mpartment pharmaco-kinetic model is used in simultaneous non-linear re gression analysis of existing experiments. Data on Cd, PCB's and PAH's are analyzed. The contribution of physiological determined variables as body size and tissue composition are evaluated on its influence on the pharmaco-kinetics of the xenobiotics. Internal partitioning over b ody fractions is related to log K(ow) values of the organic compounds. Values of the bioconcentration factor (BCF) are evaluated in relation to physiological determined variables as body size, stored energy res erves and accumulated reproductive output.