CARBONIC-ANHYDRASE INHIBITORS .21. ARYLSULFONYLHYDRAZIDES AND THEIR CU(II) COMPLEXES ARE NONCOMPETITIVE ISOZYME-II INHIBITORS

Authors
SUPURAN CT MIRONOV V TUDOR V BANCIU MD
Citation
Ct. Supuran et al., CARBONIC-ANHYDRASE INHIBITORS .21. ARYLSULFONYLHYDRAZIDES AND THEIR CU(II) COMPLEXES ARE NONCOMPETITIVE ISOZYME-II INHIBITORS, Revue Roumaine de Chimie, 39(5), 1994, pp. 587-592
Citations number
20
Categorie Soggetti
Chemistry
Journal title
Revue Roumaine de Chimie → ACNP
ISSN journal
00353930
Volume
39
Issue
5
Year of publication
1994
Pages
587 - 592
Database
ISI
SICI code
0035-3930(1994)39:5<587:CI.AAT>2.0.ZU;2-G
Abstract
Aryisulfonylhydrazides were investigated kinetically by a stopped-flow technique for the CO2 hydration reaction catalyzed by carbonic anhydr ase (CA). A non-competitive type of interaction was evidenced, similar ly with that of the classic inhibitors, the aromatic/heterocyclic sulf onamides. Cu(II) complexes of tosylhydrazide on the other hand showed a totally different coordination behavior as compared to the complexat ion of Zn(II) within the enzyme active site. The three novel Cu(II) co mplexes prepared here were characterized by standard procedures and pr oved to be strong CA inhibitors.