Pulmonary nodules of unknown nature may be cancerous and are best trea
ted by early resection. During the past 20 years we have seen 65 patie
nts in whom asymptomatic pulmonary nodules from 5 to 20 mm in diameter
were discovered on routine roentgenograms between 1 and 4 years prior
to their referral to surgery. These patients have not been investigat
ed for cancer. Instead, they had been 'observed' or treated with antib
iotics while their nodules increased in size. At the time of referral,
29 patients had widespread metastases, 28 had locally invasive State
III lung cancer, eight had Stage I or Stage II lesions. Only 16 patien
ts had their tumors resected. Sixteen patients (24.6%) survived 1 year
or longer; six patients (9.3%) survived more than 2 years. Early rese
ction of all undiagnosed pulmonary nodules is essential. 'Expectant' o
r antibiotic treatment of these lesions should be condemned. Education
al programs for family physicians are urged.