B. Birmaher et al., FLUOXETINE FOR CHILDHOOD ANXIETY DISORDERS, Journal of the American Academy of Child and Adolescent Psychiatry, 33(7), 1994, pp. 993-999
Objective: The objective of this open study was to determine the effic
acy and safety of fluoxetine for the treatment of children and adolesc
ents with anxiety disorders. Method: Twenty-one patients with overanxi
ous disorder, social phobia, or separation anxiety disorder, who were
unresponsive to previous psychopharmacological and psychotherapeutic i
nterventions, were treated openly with fluoxetine for up to 10 months.
Patients with lifetime histories of obsessive-compulsive disorder (OC
D) or panic disorder, or with current major depression, were excluded.
Beneficial and adverse effects of fluoxetine were ascertained using t
he improvement and severity subscales of the Clinical Global Impressio
n Scale (CGIS) in two ways: (1) independent chart reviews by two child
psychiatrists and (2) prospective assessments by the treating nurses
and the patients' mothers. Results: Eighty-one percent (n = 17) of pat
ients showed moderate to marked improvement in anxiety symptoms. The s
everity of anxiety as measured by the CGIS was also significantly redu
ced from marked to mild (effect size: 2.3). There were no significant
side effects. Conclusions: These results suggest that fluoxetine may b
e an effective and safe treatment for nondepressed children and adoles
cents with anxiety disorders other than OCD and panic disorder. Future
investigations using double-blind, placebo-controlled methodologies a
re warranted.