The diagnostic role of endoscopic retrograde cholangiopancreatography
(ERCP) is improved by the use of brushing, according to samples analys
is by flow cytometry, cell image analysis, or even molecular biology.
Prevention of complications requires high expertise levels and ERCP sh
ould not be performed if it cannot be followed by the appropriate endo
scopic therapy for logistic reasons. At present, it is clearly the fir
st choice technique for treatment of gallstone pancreatitis, common bi
le duct (CBD) stones, treatment of benign biliary stricture, or pallia
tion of biliopancreatic malignancies. The respective roles of classic
and self-expanding metal stents are becoming more precise and new mate
rials are still in development that might improve the long-term patenc
y of the stents. Laparoscopic cholecystectomy is associated with an in
crease of postoperative CBD injuries and ERCP plays a major role in th
eir management. The incidence of biliary injuries could be reduced by
an optimization of surgical and endoscopic collaboration, limiting the
necessity of perioperative approach to the CBD. Techniques like endos
copic ultrasonography or magnetic nuclear resonance could replace stri
ctly diagnostic ERCP in selected situations.