Although previous research has shown that childhood adversity has long
-term effects on adult depression, little is known about the causal pa
thways involved in these effects. In this report data from a two-wave
longitudinal survey of the U.S. household population are used to study
these pathways as they affect the association between childhood famil
y violence and adult recurrence of depression. We focus on recurrence
of depression because most episodes of clinically significant depressi
on in adulthood occur to persons with a history of depression. We find
that chronic interpersonal stress in adulthood mediates the effect of
childhood family violence on recurrence of depression, and that child
hood family violence modifies the effect of chronic adult interpersona
l stress on recurrence of depression. Furthermore, in the absence of c
hronic adult interpersonal stress there is no association between chil
dhood family violence and adult recurrence of depression.