ALTERATION IN THE ANTIGENIC STRUCTURE OF M1-PROTEIN OF INFLUENZA-A VIRUS MUTANT RESISTANT TO A NEW ANTIVIRAL COMPOUND MOPYRIDONE

Authors
GALABOV AS KHRISTOVA ML UZUNOV S WASSILEWA L BUCHER DJ KHARITONENKOV IG
Citation
As. Galabov et al., ALTERATION IN THE ANTIGENIC STRUCTURE OF M1-PROTEIN OF INFLUENZA-A VIRUS MUTANT RESISTANT TO A NEW ANTIVIRAL COMPOUND MOPYRIDONE, Acta virologica, 38(1), 1994, pp. 5-10
Citations number
13
Categorie Soggetti
Virology
Journal title
Acta virologica → ACNP
ISSN journal
0001723X
Volume
38
Issue
1
Year of publication
1994
Pages
5 - 10
Database
ISI
SICI code
0001-723X(1994)38:1<5:AITASO>2.0.ZU;2-Z
Abstract
Using 14 monoclonal antibodies (MoAbs) in solid-phase ELISA it was fou nd that influenza virus A/Hong Kong/1/68 (H3N2) mutants resistant to t he antiviral compound mopyridone as compared to the mopyridone-sensiti ve mutant manifested significant changes in the antigenic structure (s ites 1A, 2 and 3) of M1 protein. No differences in M1 were found betwe en rimantadine-resistant and rimantadine-sensitive mutants of influenz a virus A(H3N2).