SYNTHESIS AND BIOLOGICAL-ACTIVITY OF 4A4''-DISUBSTITUTED AVERMECTINS

Authors
JONES TK CHU L MROZIK H SLAYTON L RAFALKO B GOLDMANN ML SHOOP WL MARGIATTO G FISHER MH
Citation
Tk. Jones et al., SYNTHESIS AND BIOLOGICAL-ACTIVITY OF 4A4''-DISUBSTITUTED AVERMECTINS, Journal of agricultural and food chemistry, 42(8), 1994, pp. 1786-1790
Citations number
23
Categorie Soggetti
Food Science & Tenology",Agriculture,"Chemistry Applied
Journal title
Journal of agricultural and food chemistry → ACNP
ISSN journal
00218561
Volume
42
Issue
8
Year of publication
1994
Pages
1786 - 1790
Database
ISI
SICI code
0021-8561(1994)42:8<1786:SABO4A>2.0.ZU;2-S
Abstract
Allylic oxidation of avermectin B-1 and C-4''-substituted avermectin B -1 analogues at C-4a followed by derivatization of the C-4a oxygen pro vides compounds that have an improved safety profile, as judged by mou se LD(50) data, and are substantially more potent than avermectin B-1 against flies.