CHARACTERIZATION OF A YEAST ARTIFICIAL CHROMOSOME FROM HUMAN-CHROMOSOME BAND 13Q12 CONTAINING THE FLT1 AND FLT3 RECEPTOR-TYPE TYROSINE KINASE GENES

Authors
IMBERT A ROSNET O MARCHETTO S OLLENDORFF V BIRNBAUM D PEBUSQUE MJ
Citation
A. Imbert et al., CHARACTERIZATION OF A YEAST ARTIFICIAL CHROMOSOME FROM HUMAN-CHROMOSOME BAND 13Q12 CONTAINING THE FLT1 AND FLT3 RECEPTOR-TYPE TYROSINE KINASE GENES, Cytogenetics and cell genetics, 67(3), 1994, pp. 175-177
Citations number
20
Categorie Soggetti
Cytology & Histology","Genetics & Heredity
Journal title
Cytogenetics and cell genetics → ACNP
ISSN journal
03010171
Volume
67
Issue
3
Year of publication
1994
Pages
175 - 177
Database
ISI
SICI code
0301-0171(1994)67:3<175:COAYAC>2.0.ZU;2-H
Abstract
A yeast artificial chromosome containing the two receptor-type tyrosin e kinase genes FLT1 and FLT3 was isolated, analyzed, and compared to a genomic map in order to establish their organization and linkage. FLT 1 and FLT3 are physically linked in a head-to-tail configuration and s eparated by about 150 kb. The region contains three CpG islands. Two o f them are likely to correspond to FLT1 and FLT3, whereas the third on e is suggestive of another putative, unidentified RTK gene.