Four new alkaloids were obtained from Guatteria foliosa, namely, the n
oraporphines (-)-3-methoxyputerine [1] and (+)-norguattevaline [2], th
e more highly oxidized (+)-3-methoxyguattescidine [3], and the oxoapor
phine 3-mechoxyoxoputerine [4]. Among several other known alkaloids al
so found in this same plant, (-)-3-hydroxynornuciferine, (-)-isoguatto
uregidine, and argentinine exhibited significant activity against Tryp
anosoma cruzi.