TREATMENT OF CYTOMEGALOVIRUS RETINITIS WITH INTRAVITREAL INJECTION OFLIPOSOME-ENCAPSULATED GANCICLOVIR IN A PATIENT WITH AIDS

To study its safety and efficacy in treating cytomegalovirus (CMV) ret initis, an AIDS patient received an intravitreal injection of liposome encapsulated ganciclovir in the right eye. The left eye served as a c ontrol, receiving intravitreal free ganciclovir. The right eye showed no retinal haemorrhages or detachment; however, vision declined initia lly, stabilising later. Weekly examination showed neither progression of the CMV retinitis nor new lesions in the right eye. The left eye sh owed reactivation of old CMV retinitis. Liposome encapsulated ganciclo vir reduced the number of intravitreal injections, stabilising CMV ret initis, and warrants further study.