EFFECT OF AGING AND ACETYL-L-CARNITINE ON THE ACTIVITY OF CYTOCHROME-OXIDASE AND ADENINE-NUCLEOTIDE TRANSLOCASE IN RAT-HEART MITOCHONDRIA

Authors
PARADIES G RUGGIERO FM PETROSILLO G GADALETA MN QUAGLIARIELLO E
Citation
G. Paradies et al., EFFECT OF AGING AND ACETYL-L-CARNITINE ON THE ACTIVITY OF CYTOCHROME-OXIDASE AND ADENINE-NUCLEOTIDE TRANSLOCASE IN RAT-HEART MITOCHONDRIA, FEBS letters, 350(2-3), 1994, pp. 213-215
Citations number
21
Categorie Soggetti
Biophysics,Biology
Journal title
FEBS letters → ACNP
ISSN journal
00145793
Volume
350
Issue
2-3
Year of publication
1994
Pages
213 - 215
Database
ISI
SICI code
0014-5793(1994)350:2-3<213:EOAAAO>2.0.ZU;2-X
Abstract
The effect of aging and treatment with acetyl-L-carnitine on the activ ity of cytochrome oxidase and adenine nucleotide translocase in rat he art mitochondria was studied. It was found that the activity of both t hese mitochondrial protein systems was reduced (by around 30%) in aged animals. Treatment of aged rats with acetyl-L-carnitine almost comple tely reversed this effect. Changes in the mitochondrial cardiolipin co ntent appear to be responsible for these effects of acetyl-L-carnitine .