NEUROENDOCRINE EVIDENCE FOR REDUCED SEROTONERGIC NEUROTRANSMISSION DURING HEAVY DRINKING

Authors
BALLDIN J BERGGREN U ENGEL J ERIKSSON M
Citation
J. Balldin et al., NEUROENDOCRINE EVIDENCE FOR REDUCED SEROTONERGIC NEUROTRANSMISSION DURING HEAVY DRINKING, Alcoholism, clinical and experimental research, 18(4), 1994, pp. 822-825
Citations number
21
Categorie Soggetti
Substance Abuse
Journal title
Alcoholism, clinical and experimental research → ACNP
ISSN journal
01456008
Volume
18
Issue
4
Year of publication
1994
Pages
822 - 825
Database
ISI
SICI code
0145-6008(1994)18:4<822:NEFRSN>2.0.ZU;2-C
Abstract
A fenfluramine (60 mg oral dose) challenge test was performed in 19 ma le heavy drinkers (mean daily consumption 88 g of pure alcohol). Twelv e healthy males served as controls. The prolactin and temperature resp onses to fenfluramine were significantly reduced in the group of heavy drinkers. The results suggest impaired central serotonergic neurotran smission in alcoholism, possibly involving subsensitivity in various s erotonin receptor subtypes.