VARICELLA AND THROMBOTIC COMPLICATIONS ASSOCIATED WITH TRANSIENT PROTEIN-C AND PROTEIN-S DEFICIENCIES IN CHILDREN

Authors
NGUYEN P REYNAUD J POUZOL P MUNZER M RICHARD O FRANCOIS P
Citation
P. Nguyen et al., VARICELLA AND THROMBOTIC COMPLICATIONS ASSOCIATED WITH TRANSIENT PROTEIN-C AND PROTEIN-S DEFICIENCIES IN CHILDREN, European journal of pediatrics, 153(9), 1994, pp. 646-649
Citations number
14
Categorie Soggetti
Pediatrics
Journal title
European journal of pediatrics → ACNP
ISSN journal
03406199
Volume
153
Issue
9
Year of publication
1994
Pages
646 - 649
Database
ISI
SICI code
0340-6199(1994)153:9<646:VATCAW>2.0.ZU;2-D
Abstract
We report six cases of protein S deficiency secondary to varicella. Fi ve cases were complicated by thrombotic and vascular events, namely pu rpura fulminans and necrotic vasculitis, deep vein thrombosis and stro ke. Two cases were associated with protein C deficiency and one case r evealed a heterozygous factor XII deficiency. The underlying mechanism of this acquired protein S deficiency is unclear but could be related to a direct effect of zoster virus.