Single-sweep visual evoked potential analysis would be useful in clini
cal electrophysiology practice because it would make possible the eval
uation of transient phenomena, but recording single-sweep visual evoke
d potentials is difficult because of the low signal-noise ratio. To in
crease this ratio we used a filter based on an autoregressive with exo
genous input model. We studied a group of 12 diabetic patients matched
with a control group of 14 normal subjects. The model, in most cases,
allowed us to extrapolate the P100 component from each single sweep o
f visual evoked potential. The visual evoked potential values obtained
by means of averaging were not significantly different in the groups
studied, but single-sweep analysis showed different distribution of th
e P100 component amplitude. The preliminary results of our study evide
nced differences in the amplitude and latency distribution of normal a
nd diabetic subjects, thus confirming the power of this new technique
and its ability to obtain some information that is masked by the avera
ging method.