URETHRAL SYNDROME - CLINICAL-RESULTS WITH ANTIBIOTICS ALONE OR COMBINED WITH ESTROGEN

The urethral syndrome is very frequent in women but the etiology is un known. In all 77 patients suffering from the syndrome, endoscopy revea led characteristic lesions in the trigonal area. As unidentified bacte ria may be responsible, a microbiological investigation was carried ou t. Wide-spectrum or specific antibiotic therapy was prescribed as requ ired. All patients were also randomized to 2 groups to assess the effi cacy of local estrogen therapy. The authors concluded that wide-spectr um antibiotic therapy with macrolide and mepartricin should be the fir st choice of treatment and that local administration of estrogen does not significantly enhance the benefits achieved through antibiotic the rapy. A detailed microbiological investigation is necessary when sympt oms persist. Overall a positive result was obtained in 75.32% of the c ases (58 patients). The presence of Streptococci negatively influenced the results of specific antibiotic therapy.