TREATMENT OF TESTICULAR SEMINOMA IN PATIENTS WITH HIV-INFECTION - REPORT OF 2 CASES

The problem of adequate management of testicular germ cell tumors in p atients with AIDS is increasingly important, as reflected by the incre asing number of reports on the unclear pathogenetic association of the two conditions. Two HIV-positive patients (32 and 39 years old) at CD C stages II and IIb with pure seminoma have been treated. Both patient s initially underwent semicastration. One patient (tumor stage IIa) th en had retroperitoneal radiotherapy, and the other (tumor stage IIc) f our cycles of carboplatin therapy. They have had no relapse after 35 a nd 14 months, respectively, and there has been no progression in the H IV infection stage. Stage-oriented treatment for testicular germ-cell tumors can, in principle, be applied in patients with HIV infection. R adiotherapy and chemotherapy do not necessarily lead to a deterioratio n in the clinical state of health of the immune status of HIV-infected patients and carboplatin monotherapy is an effective treatment with f ew side effects in patients with metastatic seminoma.