The frequencies of laryngeal symptoms and smoking habits were investig
ated in 60 patients referred to 24-hour pH-metry because of esophagus-
related symptoms. Group 1 comprised 30 consecutively referred patients
who exhibited pathological gastroesophageal reflux by pH-metry, and g
roup 2 comprised 30 consecutively referred patients who showed normal
pH-metry. The patients, as well as 30 age-matched controls (not invest
igated by pH-metry), answered a questionnaire about voice problems and
smoking habits. The 60 patients reported a frequency of voice problem
s comparable to the 30 controls. The various voice problems did not di
ffer significantly in frequency between refluxers and patients with a
normal reflux pattern in spite of the fact that there were significant
ly more smokers among the refluxers compared to non-refluxers. We conc
luded that voice problems were not more common among patients with abn
ormal reflux patterns than among patients with a normal reflux defence
.