PREMARIN-INDUCED ISCHEMIC COLITIS

There are numerous literature reports of oral contraceptive-induced (e strogen and progesterone) ischemic bowel disease. However, Premarin-in duced (equine conjugated estrogen) intestinal ischemia has rarely been reported. We describe three cases of Premarin-induced ischemic coliti s. In contrast to oral contraceptive-induced ischemic colitis, Premari n-induced ischemia is restricted to the colon, has not required surgic al therapy, can have a chronic or chronic intermittent course, may be reversible despite continued usage of Premarin, and may present with n onspecific abdominal and colonic symptoms.