AUTOIMMUNE CHRONIC ACTIVE HEPATITIS RESPONSIVE TO IMMUNOSUPPRESSIVE THERAPY EVOLVING INTO A TYPICAL PRIMARY BILIARY-CIRRHOSIS SYNDROME - A CASE-REPORT

Citation
Y. Horsmans et al., AUTOIMMUNE CHRONIC ACTIVE HEPATITIS RESPONSIVE TO IMMUNOSUPPRESSIVE THERAPY EVOLVING INTO A TYPICAL PRIMARY BILIARY-CIRRHOSIS SYNDROME - A CASE-REPORT, Journal of hepatology, 21(2), 1994, pp. 194-198
Citations number
16
Categorie Soggetti
Gastroenterology & Hepatology
Journal title
ISSN journal
01688278
Volume
21
Issue
2
Year of publication
1994
Pages
194 - 198
Database
ISI
SICI code
0168-8278(1994)21:2<194:ACAHRT>2.0.ZU;2-#
Abstract
The evolution from a characteristic picture of autoimmune chronic hepa titis type I to primary biliary cirrhosis is reported in a middle-aged woman. The initial diagnosis of autoimmune chronic liver disease was based on clinical, bio-serological and histological grounds. It was fu rther confirmed by complete remission following immunosuppressive trea tment and prompt relapses at the time of therapy withdrawal. After 7 y ears, the characteristics of liver disease were altered with increased biochemical cholestasis and serum IgM concentrations, positivation of previously negative anti-M2 antimitochondrial antibodies and the appe arance of a typical histological picture of stage I primary biliary ci rrhosis. We believe that this is the first reported case in which auto immune chronic hepatitis highly responsive to immunosuppressive therap y has been followed by the development of a characteristic picture of primary biliary cirrhosis. (C) Journal of Hepatology.