This reassessment of the long debate about Friedman's thesis on the po
intlessness of testing assumptions in economics shows that Friedman's
three famous examples, on which a large part of the credit given to th
is thesis is based, far from substantiating it, can be used to establi
sh radically opposite conclusions. Furthermore, it is shown that this
so-called ''instrumentalist'' thesis, when applied by Friedman to econ
omics, is of a quite different nature and raises much more serious pro
blems than the standard instrumentalist thesis devised by some methodo
logists of physics. To disentangle these ambiguities concerning realis
m and instrumentalism applied to physics or to economics, this paper r
efers to Van Fraassen's ''constructive empiricism'', which is helpful
in reformulating, in a more satisfactory way, the essentials of Friedm
an's considerations about empiricism and anti-realism.