SYNTHESIS OF [1-C-11]-2-OCTYNOIC ACID, [1-C-11]-2-DECYNOIC ACID AND [1-C-11]-3-(R,S)-METHYLOCATANOIC ACID AS POTENTIAL MARKERS FOR PET STUDIES OF FATTY-ACID METABOLISM

[1-C-11]-2-Octynoic acid, [1-C-11]-2-decynoic acid and [1-C-11]-3-(R,S )-methyloctanoic acid have been synthesized in order to evaluate these compounds as PET (Positron Emission Tomography) tracers for imaging i n vivo medium-chain acyl-CoA dehydrogenase and medium-chain fatty acid utilization. The synthesis was performed by the Grignard reaction bet ween alkylmagnesium bromides and [C-11]CO2. The radiochemical yields o f [1-C-11]-2-octynoic acid, [1-C-11]-2-decynoic acid, and [1-C-11]-3-( R,S)-methyloctanoic acid were 10, 7 and 1% based on the [C-11]CO2 used respectively. Radiochemical purity was >99% in all cases.