SYNTHESIS OF [1-C-11]-2-OCTYNOIC ACID, [1-C-11]-2-DECYNOIC ACID AND [1-C-11]-3-(R,S)-METHYLOCATANOIC ACID AS POTENTIAL MARKERS FOR PET STUDIES OF FATTY-ACID METABOLISM
H. Kawashima et al., SYNTHESIS OF [1-C-11]-2-OCTYNOIC ACID, [1-C-11]-2-DECYNOIC ACID AND [1-C-11]-3-(R,S)-METHYLOCATANOIC ACID AS POTENTIAL MARKERS FOR PET STUDIES OF FATTY-ACID METABOLISM, Journal of labelled compounds & radiopharmaceuticals, 39(3), 1997, pp. 181-193
Citations number
16
Categorie Soggetti
Chemistry Analytical","Pharmacology & Pharmacy","Biochemical Research Methods
[1-C-11]-2-Octynoic acid, [1-C-11]-2-decynoic acid and [1-C-11]-3-(R,S
)-methyloctanoic acid have been synthesized in order to evaluate these
compounds as PET (Positron Emission Tomography) tracers for imaging i
n vivo medium-chain acyl-CoA dehydrogenase and medium-chain fatty acid
utilization. The synthesis was performed by the Grignard reaction bet
ween alkylmagnesium bromides and [C-11]CO2. The radiochemical yields o
f [1-C-11]-2-octynoic acid, [1-C-11]-2-decynoic acid, and [1-C-11]-3-(
R,S)-methyloctanoic acid were 10, 7 and 1% based on the [C-11]CO2 used
respectively. Radiochemical purity was >99% in all cases.