CONCENTRATION-DEPENDENCE OF ADENOSINE AND THE PROTECTION OF RAT CORTICAL-NEURONS DURING ANOXIA

Authors
DONAGHY KM SCHOLFIELD CN
Citation
Km. Donaghy et Cn. Scholfield, CONCENTRATION-DEPENDENCE OF ADENOSINE AND THE PROTECTION OF RAT CORTICAL-NEURONS DURING ANOXIA, Brain research, 656(1), 1994, pp. 174-176
Citations number
19
Categorie Soggetti
Neurosciences
Journal title
Brain research → ACNP
ISSN journal
00068993
Volume
656
Issue
1
Year of publication
1994
Pages
174 - 176
Database
ISI
SICI code
0006-8993(1994)656:1<174:COAATP>2.0.ZU;2-G
Abstract
Aglycaemic/anoxic slices of rat olfactory cortex lose all electrical a ctivity. On reoxygenation, 10 mu M adenosine enhanced recovery from 23 +/- 7% to 53 +/- 12%; an increased tissue endurance of 5-7 min. 100 m u M adenosine slightly depressed recovery to 11.5 +/- 2.1%. Dipyridamo le increased whereas adenosine deaminase reduced recovery. These obser vations question the therapeutic effectiveness of high adenosine conce ntrations.