Bm. Swahn et al., SYNTHESIS OF C-14-LABELED -DIMETHYL-3-(PHOSPHONOMETHYL)-2-QUINOLINEPROPANOIC ACID, Journal of labelled compounds & radiopharmaceuticals, 39(3), 1997, pp. 259-266
Citations number
7
Categorie Soggetti
Chemistry Analytical","Pharmacology & Pharmacy","Biochemical Research Methods
The NMDA antagonist ,7-dimethyl-3-(phosphonomethyl)-quinolinepropanoic
acid 1 was [C-14]-labelled at the 6-methyl group. The quinoline synth
esis started from 4-bromo-3-methylaniline and the radiolabel was intro
duced late in the synthetic scheme. The synthesis was accomplished by
a NiCl2(dppp)(2)-catalyzed coupling of the 6-bromoquinoline derivative
6 with a zinc reagent made from [C-14]-methyl iodide.