SYNTHESIS OF C-14-LABELED -DIMETHYL-3-(PHOSPHONOMETHYL)-2-QUINOLINEPROPANOIC ACID

Authors
SWAHN BM ANDERSSON F PELCMAN B SODERBERG J CLAESSON A
Citation
Bm. Swahn et al., SYNTHESIS OF C-14-LABELED -DIMETHYL-3-(PHOSPHONOMETHYL)-2-QUINOLINEPROPANOIC ACID, Journal of labelled compounds & radiopharmaceuticals, 39(3), 1997, pp. 259-266
Citations number
7
Categorie Soggetti
Chemistry Analytical","Pharmacology & Pharmacy","Biochemical Research Methods
Journal title
Journal of labelled compounds & radiopharmaceuticals → ACNP
ISSN journal
03624803
Volume
39
Issue
3
Year of publication
1997
Pages
259 - 266
Database
ISI
SICI code
0362-4803(1997)39:3<259:SOC->2.0.ZU;2-T
Abstract
The NMDA antagonist ,7-dimethyl-3-(phosphonomethyl)-quinolinepropanoic acid 1 was [C-14]-labelled at the 6-methyl group. The quinoline synth esis started from 4-bromo-3-methylaniline and the radiolabel was intro duced late in the synthetic scheme. The synthesis was accomplished by a NiCl2(dppp)(2)-catalyzed coupling of the 6-bromoquinoline derivative 6 with a zinc reagent made from [C-14]-methyl iodide.