STUDIES ON THE BIOLOGICAL EFFECTS OF OZONE .5. EVALUATION OF IMMUNOLOGICAL PARAMETERS AND TOLERABILITY IN NORMAL VOLUNTEERS RECEIVING AMBULATORY AUTOHAEMOTHERAPY

Autohaemotherapy, after a bland treatment ex vivo of blood with ozone, is a fairly unknown medical procedure claimed to have therapeutic val ue in viral diseases and neoplasms. Having already shown that ozone ac ts as a mild inducer of cytokines, we have undertaken an investigation in normal rabbits and in normal volunteers aiming to evaluate eventua l changes of some cytokine levels in plasma as well as of immunologica l parameters such as the Mr protein, neopterin, beta 2-microglobulin a nd of some acute-phase proteins after single or repeated autohaemother apy. We have also evaluated the potential development of side-effects. This study is the first one to show that autohaemotherapy can activat e an immunological marker in normal subjects without procuring any tox ic effects.