A GENERAL-METHOD FOR COUPLING UNPROTECTED PEPTIDES TO BROMOACETAMIDO PORPHYRIN TEMPLATES

Authors
CHOMA CT KAESTLE K AKERFELDT KS KIM RM GROVES JT DEGRADO WF
Citation
Ct. Choma et al., A GENERAL-METHOD FOR COUPLING UNPROTECTED PEPTIDES TO BROMOACETAMIDO PORPHYRIN TEMPLATES, Tetrahedron letters, 35(34), 1994, pp. 6191-6194
Citations number
20
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
35
Issue
34
Year of publication
1994
Pages
6191 - 6194
Database
ISI
SICI code
0040-4039(1994)35:34<6191:AGFCUP>2.0.ZU;2-N
Abstract
An N-terminal cysteine is used to displace bromide from a bromoacetyla ted porphyrin to yield a thioether linkage between the peptide and the template. Unlike amide coupling reactions, this approach should be co mpatible with any peptide sequence provided there is only a single cys teine.