SELECTIVE DEPROTECTION OF ESTERS USING MAGNESIUM AND METHANOL

Authors
XU YC LEBEAU E WALKER C
Citation
Yc. Xu et al., SELECTIVE DEPROTECTION OF ESTERS USING MAGNESIUM AND METHANOL, Tetrahedron letters, 35(34), 1994, pp. 6207-6210
Citations number
15
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
35
Issue
34
Year of publication
1994
Pages
6207 - 6210
Database
ISI
SICI code
0040-4039(1994)35:34<6207:SDOEUM>2.0.ZU;2-S
Abstract
The use of magnesium metal in methanol for the deprotection of alkyl e sters is described. This mild reagent also provides good to excellent selectivity to cleave different esters. The order of the reactivity of this reagent towards acyl cleavages was found to be: p-nitrobenzoate > acetate > benzoate > pivaloate >> trifluroacetamide.