TOTAL SYNTHESIS OF 11-R,12-R-DIHYDROXYEICOSATRIENOIC ACID, A METABOLITE OF THE CYTOCHROME-P-450 EPOXYGENASE PATHWAY

Authors
WANG SS ROKACH J
Citation
Ss. Wang et J. Rokach, TOTAL SYNTHESIS OF 11-R,12-R-DIHYDROXYEICOSATRIENOIC ACID, A METABOLITE OF THE CYTOCHROME-P-450 EPOXYGENASE PATHWAY, Tetrahedron letters, 35(34), 1994, pp. 6239-6242
Citations number
13
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
35
Issue
34
Year of publication
1994
Pages
6239 - 6242
Database
ISI
SICI code
0040-4039(1994)35:34<6239:TSO1AA>2.0.ZU;2-T
Abstract
The first total and enantioselective synthesis of 11-R,12-R-dihydroxy- 5,8,14-eicosatrienoic acid 7 is reported. We have used the catbohydrat e 2-deoxy-D-glucose as a masked 1,6-dialdehyde precursor 20 to perform the synthesis. The availability of this material will allow, among ot her things, the testing of the hypothesis that it can be a biochemical precursor to 12-R-HETE in vivo.