A NEW SYNTHESIS OF 1-BETA-METHYLCARBAPENEMS USING NBS-PROMOTED CYCLIZATION AS A KEY STEP

Authors
SAKURAI O TAKAHASHI M OGIKU T HAYASHI M HORIKAWA H IWASAKI T
Citation
O. Sakurai et al., A NEW SYNTHESIS OF 1-BETA-METHYLCARBAPENEMS USING NBS-PROMOTED CYCLIZATION AS A KEY STEP, Tetrahedron letters, 35(34), 1994, pp. 6317-6320
Citations number
24
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
35
Issue
34
Year of publication
1994
Pages
6317 - 6320
Database
ISI
SICI code
0040-4039(1994)35:34<6317:ANSO1U>2.0.ZU;2-K
Abstract
A novel construction of 1 beta-methylcarbapenem skeleton has been achi eved by use of N-bromosuccinimide(NBS)-promoted cyclization as a key s tep. The mechanism of the stereospecific cyclization leading to 1 beta -methylcarbapenam is also discussed.