A NOVEL DISPLACEMENT ROUTE TO P-CHIRAL PHOSPHINE OXIDES OF HIGH ENANTIOMERIC PURITY

Authors
CARDELLICCHIO C FIANDANESE V NASO F PACIFICO S KOPROWSKI M PIETRUSIEWICZ KM
Citation
C. Cardellicchio et al., A NOVEL DISPLACEMENT ROUTE TO P-CHIRAL PHOSPHINE OXIDES OF HIGH ENANTIOMERIC PURITY, Tetrahedron letters, 35(34), 1994, pp. 6343-6346
Citations number
30
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
35
Issue
34
Year of publication
1994
Pages
6343 - 6346
Database
ISI
SICI code
0040-4039(1994)35:34<6343:ANDRTP>2.0.ZU;2-8
Abstract
Reactions of (R)-(1-chlorovinyl)methylphenylphosphine oxide with aryl and alkenyl Grignard reagents result in highly stereoselective displac ement of the halovinyl group and afford virtually enantiomerically pur e arylmethylphenyl and alkenylmethylphenylphosphine oxides of inverted configuration at phosphorus.