A CONCISE SYNTHESIS OF CHIRAL 2-METHYL CHROMAN-4-ONES - STEREO SELECTIVE BUILDUP OF THE CHROMANOL MOIETY OF ANTI-HIV AGENT, CALANOLIDE-A

Authors
RAO AVR GAITONDE AS PRAKASH KRC RAO SP
Citation
Avr. Rao et al., A CONCISE SYNTHESIS OF CHIRAL 2-METHYL CHROMAN-4-ONES - STEREO SELECTIVE BUILDUP OF THE CHROMANOL MOIETY OF ANTI-HIV AGENT, CALANOLIDE-A, Tetrahedron letters, 35(34), 1994, pp. 6347-6350
Citations number
17
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
35
Issue
34
Year of publication
1994
Pages
6347 - 6350
Database
ISI
SICI code
0040-4039(1994)35:34<6347:ACSOC2>2.0.ZU;2-6
Abstract
Inter- and Intramolecular Houben-Hoesch reactions have been used for t he first time for the enantioselective synthesis of both the antipodes of 5,7-dimethoxy-2-methyl chroman-4-one. (R)-7-Methoxy-2-methyl chrom an-4-one has been diastereoselectively elaborated to the dimethylchrom anol moiety of calanolide A.