A group of patients with idiopathic osteoarthritis (OA) of the knee wa
s surveyed using weight-bearing radiographs and MR imaging to compare
the relative value of these methods in disease evaluation. Fifty-two p
atients with a clinical and radiological diagnosis of OA of the knee o
f relatively short duration (87%: less than or equal to 4 yr) were com
pared to a reference group of 40 age- and sex-comparable subjects with
no knee symptoms. AH patients had a complete history, physical examin
ation, standard anterior-posterior and lateral weight-bearing radiogra
phs, T-1-weighted, and FLASH MR images in both knees. The prevalence o
f MRI abnormalities was significantly greater in patients with OA of t
he knee in all radiographic grades (Kellgren and Lawrence) compared to
the reference subjects. Significant differences were encountered for
synovial thickening (OA, 73%; reference, 0%), synovial fluid (60%; 7%)
, meniscal degeneration (52%; 7%), osteophytes (67%; 12%), and subchon
dral bone involvement (65%; 7%), even in the patients at the mild end
of the osteoarthritic spectrum, indicating the exquisite sensitivity o
f MRI compared with weight-bearing radiographs.