MICROSOMAL AND PEROXISOMAL FATTY-ACID OXIDATION IN LIVER OF RATS WITHBILE-DUCT LIGATION AND 2-3RDS HEPATECTOMY

Authors
ORELLANA M AVALOS N ABARCA M VALDES E
Citation
M. Orellana et al., MICROSOMAL AND PEROXISOMAL FATTY-ACID OXIDATION IN LIVER OF RATS WITHBILE-DUCT LIGATION AND 2-3RDS HEPATECTOMY, Comparative biochemistry and physiology. Part C, Pharmacology toxicology & endocrinology, 116(1), 1997, pp. 33-37
Citations number
27
Categorie Soggetti
Biology,"Pharmacology & Pharmacy",Toxicology
Journal title
Comparative biochemistry and physiology. Part C, Pharmacology toxicology & endocrinology → ACNP
ISSN journal
13678280
Volume
116
Issue
1
Year of publication
1997
Pages
33 - 37
Database
ISI
SICI code
1367-8280(1997)116:1<33:MAPFOI>2.0.ZU;2-Y
Abstract
Microsomal cytochrome P450 and peroxisomal activity were studied in li ver of rats I days after two-thirds hepatectomy or bile duct ligation (BDL). Both surgical models decreased the hepatic microsomal cytochrom e P450 content, but only cholestasis, produced by BDL, decreased the m icrosomal metabolism of lauric acid and aminopyrine, peroxisomal fatty acid beta-oxidation and catalase activity. The microsomal and peroxis omal activities responded in a coordinate way to cholestasis and two-t hirds hepatectomy. These results suggest a cause-effect relationship b etween the microsomal cytochrome P450 and peroxisomal activity. Copyri ght (C) 1997 Elsevier Science Inc.